Protecting endothelial function: A novel therapeutic target of ATP-sensitive potassium channel openers
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چکیده
منابع مشابه
Protecting endothelial function: A novel therapeutic target of ATP-sensitive potassium channel openers.
Endothelial dysfunction is commonly observed in patients with hypertension, type II diabetes mellitus, and hypercholesteremia and is considered to be an early event in the changes accompanying atherosclerosis [1,2]. Disruption of normal endothelial function leads to loss of vasomotor control, reduced production of nitric oxide (NO), formation of a procoagulant surface, and promotion of inflamma...
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Dr. Grover’s very kind and complimentary remarks about the recent review [l] on ATP-sensitive potassium channel openers during ischemia and reperfusion are much appreciated. One point, however, causes Dr. Grover considerable concern-this is the citation of (and by implication a presumed agreement with) the comments in the paper by Richer et al. [2]. This paper was critical of the conclusions of...
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PURPOSE To evaluate the expression of ATP-sensitive potassium (K(ATP)) channel subunits and study the effect of K(ATP) channel openers diazoxide and nicorandil on intraocular pressure (IOP) in an in vivo mouse model. METHODS Expression of K(ATP) channel subunits in normal C57BL/6 mouse eyes was studied by immunohistochemistry and confocal microscopy. Wild-type C57BL/6 mice were treated with K...
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OBJECTIVE Endothelial dysfunction is an early risk factor for cardiovascular disease and hypertension. Mechanisms that participate in endothelial dysfunction include reduced nitric oxide (NO) generation and increased endothelin-1 (ET-1) generation. Endothelial ATP-sensitive potassium (K(ATP)) channels are responsible for maintaining the resting potential of endothelial cells and modulating the ...
متن کاملThe therapeutic agents that target ATP-sensitive potassium channels.
ATP-sensitive potassium (K(ATP)) channels are a major drug target for the treatment of type-2 diabetes. K(ATP) channels are ubiquitously expressed and link the metabolic state to electrical excitability. In pancreatic β-cells, K(ATP) channels are crucial in the regulation of glucose-induced insulin secretion. Also, K(ATP) channels are involved in the protection against neuronal seizures and isc...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2007
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2006.11.014